Corydalis yanhusuo root found to relieve pain in new study
Corydalis yanhusuo root may be used to treat chronic pain
Dehydrocorybulbine was pain relieving compound found in Corydalis yanhusuo root
Corydalis yanhusuo root has been used for centuries as Chinese herbal remedy
Corydalis yanhusuo root, an ancient Chinese remedy, could be used to treat chronic pain. New research has shown that Corydalis yanhusuo root contains pain-relieving ingredient dehydrocorybulbine, which does not lose effectiveness over time as opiate drugs do.
Corydalis yanhusuo is a member of the poppy family, and has been used for centuries as an herbal remedy for stomach pain and menstrual cramps. It also contains several alkaloids that reportedly help improve blood circulation and relieve chest pain.
The dehydrocorybulbine contained in the Corydalis yanhusuo root does not act on morphine receptors, but on one that binds dopamine. Dopamine helps control the reward and pleasure centers and helps regulate movement and emotional response.
Unlike morphine, Corydalis yanhusuo root does not lead to tolerance, and therefore does not induce dependence on the drug.
The new study, conducted by Olivier Civelli, a team from UC Irvine colleagues and other researchers in China, found that the dehydrocorybulbine from Corydalis yanhusuo root reduced inflammatory pain and neuropathic pain.
“Our study reports the discovery of a new natural product that can relieve pain. This analgesic acts in animal assays against the three types of pain that afflict humans, including acute, inflammatory, and neuropathic or chronic pain,” states Oliver Civelli.
The discovery was made through the herbalome project which is aimed at cataloguing all chemical components of traditional Chinese remedies.
Oliver Civelli states, “Today the pharmaceutical industry struggles to find new drugs. Yet for centuries people have used herbal remedies to address myriad health conditions, including pain. Our objective was to identify compounds in these herbal remedies that may help us discover new ways to treat health problems. We’re excited that this one shows promise as an effective pharmaceutical. It also shows a different way to understand the pain mechanism.”
During the study, 10 traditional Chinese remedies have been tested and approximately 500 compounds that were thought to be analgesics. The dehydrocorybulbine in Corydalis yanhusuo root was the only one able to relieve pain.