According to a recently completed study at the University of Southampton in Southampton, England, a new, effective weight loss pill could one day replace physical exercise. A pair of professors there announced they have synthesized one molecule that actually mimics exercise by fooling cells in the body into thinking they’ve run out of energy.
The molecule, named compound 14, does this by setting off a chain reaction of unique events inside a cell. It inhibits the purpose of ATIC which is an enzyme that has a critical part in insulin signaling within a person’s body.
That results in an increase of the body’s metabolism master regulator, ZMP, in the cells. ZMP is actually what makes the cells in the body think they no longer have any energy. That sets off the central energy sensor or AMPK in the body’s cells which then compensate by increasing their metabolism and glucose.
These are the typical changes that happen when someone exercises. That, in turn, leads to weight loss.
While this study involved only giving compound 14 to mice, the researchers reported the molecule does appear to reduce the glucose levels and lower the weight of the body. If this effect can be verified and the compound itself be proven safe for human consumption, it could lead to a new treatment in pill form for things such as obesity or type 2 diabetes.
Study co-author and Associate Professor in Integrative Physiology at the university Dr Felino Cagampang reported that this discovery could very well change the way in which overweight people get into shape. He states: “This new molecule seems to reduce glucose levels and at the same time decrease body weight, but only if the subject is obese.”
The professors concluded that they will next be researching the effectiveness of weight reduction in human beings through long-term treatment.
New Weight Loss Pill Mimics Exercise?